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Sorafenib, a multiple kinase inhibitor and FDA approved drug, was revealed to induce ferroptosis and exhibit anti-tumor effects in various cancer cell lines such as hepatocellular carcinoma cells, human kidney cancer cells and nonsmall cell lung cancer [131, 132]

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Additional information Communicated by Anatolii Kubyshkin

Beyond dietary modifications, LC-FAOD (VLCAD [very long-chain acyl-CoA dehydrogenase], MTP/LCHAD, CACT [carnitine acylcarnitine translocase], CPT IA, CPT II) can be effectively and safely treated with an anaplerotic drug, triheptanoin

-thalassemia patients experience increased iron release from reticuloendothelial cells and intestinal absorption of iron, ultimately resulting in iron overload