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Cancer Immunol Res (2017) 5(8):64253

D-cycloserine: a ligand for the N -methyl-D-aspartate coupled glycine receptor has partial agonist characteristics

therefore, imidazole ketone erastin (IKE) and piperazine erastin were developed (which are more soluble in water), and both show strong antitumor effects against diffuse large B-cell lymphoma (DLBCL) and fibrosarcoma 64,65