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Taken together, these data demonstrate that mitochondrial function is intrinsically linked to 5FU sensitivity, and that its inhibition may provide an opportunity to increase 5FU efficacy

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Mechanistically, the HGF/C-Met signaling pathway induces the activation of multiple downstream signaling cascades, including the JAK/STAT3, Ras/Raf, and PI3K/AKT/NF-B pathways, throughout the liver repair process