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Precision trials targeting specific PD subtypes (e.g., PINK1/Parkin mutations) and exploration of optimal dosing ratios for combination therapies (e.g., NTFs signaling activators + mitochondrial-targeted antioxidants) may help improve translational success, though such strategies require careful design to address complexity in patient heterogeneity and potential drug-drug interactions

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It is these effects that draw the attention of athletes to nitric oxide