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DNA demethylation encompasses the removal of a methyl group (-CH3) from DNA and proceeds through two fundamental mechanisms: active demethylation, which implicates the TET enzyme family catalyzing the oxidation of the methyl group on cytosine, and passive demethylation, where DNA demethylase enzymes directly excise the methyl group from cytosine ( Figure 1 ) (3739)

Elevated levels of intracellular calcium are considered to be a key factor in the subsequent stages that may lead to growth hormone release

doi: 10.1073/pnas.11198z36109 48 VinogradovaMGehlingVSGustafsonAAroraSTindellCAWilsonCet al

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