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Peptide structure-activity relationship (SAR) analysis : Cagrilintide's engineered sequence and conformational stability offer a robust framework for comparative SAR studies

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about the relationship between porosity and water absorption, to the authors knowledge, this has not been systematically investigated 23,24

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(1998) characterized the compounds as Ang IV receptor agonists and some of them, e.g., 8 with the straight four-carbon chain of the Nle residue at position one, exhibited very high affinity to the binding site (IC50 values 30-fold higher affinity (Ki = 1.7 nM) than Ang IV and improved both selectivity and metabolic stability (Lukaszuk et al., 2008