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Reactive oxygen species (ROS) generated during ischemia and early reperfusion act as signaling molecules, activating redox-sensitive transcription factors, such as nuclear factor kappa B (NF-B) and nuclear factor erythroid 2-related factor 2 (NRF2)

Acknowledgments The financial support of the Hungarian National Research, Development and Innovation Office (K-111995 and K-124131) is gratefully acknowledged

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A continuacin, la trimetilamina se transforma en otro compuesto, el xido de trimetilamina u OTMA ((CH 3 ) 3 NO), un compuesto inerte y de fcil eliminacin, en una reaccin catalizada por la enzima flavinmonooxigenasa 3 (FMO3) y que tiene lugar en el hgado