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Aquat Toxicol 148:195203

27 RenS.KalhornT

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzymatic activity that converts -ketoglutarate to 2-hydroxyglutarate

2.3 Other cells In addition to tumor cells and T cells, the TME also contains various other cell types that play important roles in tumor initiation, progression, immune evasion, and response to therapy