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Furthermore, HIV can elevate cellular iron levels by utilizing hepcidin-mediated degradation of ferroportin, which in turn enhances HIV transcription, replication, and release [83, 84]

To investigate how metformin exerted its antioxidant effects, we first examined the expression of Nrf2 and its downstream regulatory protein HO-1 in the chondrocytes exposed to H 2 O 2 , with or without metformin treatment

Some studies have found that people with FM have lower levels of 5-HT in their cerebrospinal fluid than healthy controls, which may contribute to the development of pain and other symptoms 19

The availability of PHGDH inhibitors presents an exciting opportunity for preclinical and clinical trials targeting patients with PHGDH-amplified tumors [38]

Consequently, the therapeutic efficacy of TCM and natural products may be enhanced via the action of the GM