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This triggers synergistic Fenton reactions and lipid peroxidation to induce tumor-specific ferroptosis while minimizing oxidative damage to normal tissues in radiotherapy (201)

Data Availability Statement The results/data/figures in this manuscript have not been published elsewhere, nor are they under consideration by another publisher.

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evaluating the radio-protective effect of cerium oxide nanoparticles in normal and tumor cells, the treatment was almost 99% effective in protecting against radiotherapy in a normal human breast cell line but showed no significant effectiveness against a human breast tumor cell line (Tarnuzzer et al., 2005)

Methods Chemical syntheses Overview of synthesis The symmetrical disulfides, SS(CAM-TPP) 2 and SS(CAM- d 15 TPP) 2 (where CAM = carbamidomethyl), and unsymmetrical sulfides, CAM-S-CAM-TPP and CAM-S-CAM-d 15 TPP, were prepared from Dithiodiglycolic acid, SS(CM) 2 (where CM = carboxymethyl, Supplementary Fig