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Sderberg S, Livingstone DE, Eliasson M, Johnson O, Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11beta-hydroxysteroid dehydrogenase type 1 activity

Those taking tirzepatide, managed an additional 5.5% WL from randomisation, compared to those taking placebo who experienced mean weight regain of 14% from randomisation [49]

It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood

This is because nitric oxide also regulates insulin, which helps cells utilize the energy obtained from food after its digested

Broadfield, L