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Further studies are needed to define which signaling pathway is involved in A induced neuronal dysfunction, if the sensory neurons and motor neurons are shared same mechanisms, and the role of the UPS in the regulation of A accumulation in SCI

This makes MOTS-c more targeted and less likely to produce off-target gastrointestinal side effects common with metformin

In the Con-DSS group, the weight loss associated with UC was evident on the 2nd day of DSS administration

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doi: 10.1681/ASN.2012010046