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Furthermore, since metabolism of varenicline represents less than 10% of its clearance, drugs known to affect the cytochrome P450 system are unlikely to alter the pharmacokinetics of CHANTIX [see Clinical Pharmacology (12.3)]

Some applications are processed quickly, while others can take months depending on documentation and inspections

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While the Nevada Department of Taxation oversees the issuance of tobacco licenses at the state level, local jurisdictions, such as cities and counties, may have additional regulations and licensing requirements