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These changes suggest a disruption in several metabolic pathways, including the biosynthesis of phosphatidylethanolamine, fatty acid synthesis, pyruvate metabolism, and mitochondrial acetyl group transfer, as indicated by pathway enrichment analysis

The anti-CD38 phycoerythrin (PE) and anti-CD138 fluorescein isothiocyanate (FITC) antibodies, and APO-DIRECT kit (terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL)) were purchased from BD Biosciences (San Jose, CA, USA)

Additionally, it explores translational applications, including dietary interventions, probiotics, synbiotics, and fecal microbiota transplantation, emphasizing how microbiome-targeted strategies could modulate persistent symptoms and guide personalized therapy

doi: 10.1021/jf902171h 243

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