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Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

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PMID: 33732072

doi: 10.1021/cr010170+ 88 LaskowskiMJr.KatoI

Oxidative stress plays a prominent role in SARS-CoV-2 infection following recognition of the viral S-protein by angiotensin converting enzyme-2 receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production