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Berberine administration is evidenced to improve cognitive impairment and neurological deficits and reduce brain edema in rodent models of TBI

You should seek medical attention if you have taken mega doses of vitamins whether that's early on or if you have been taking them for several months and experience seizures, changes in mood, including irritability or confusion, increase in headaches or fatigue, or onset of GI [gastrointestinal] symptoms like diarrhea, vomiting or stomach cramps, stresses Czerwony

Hard contraindications active malignancy, Wilsons disease or copper metabolism disorders, pregnancy, surgery within two weeks apply at any duration

doi: 10.1007/s11136-018-1877-5 33 HerreroM

It plays a key role in protecting the organism from oxidative stress in both tissues and cells, by catching free radicals and is therefore one of the main antioxidant systems in our body