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Herbal products and the liver: a review of adverse effects and mechanisms

It was observed that both HlGST and HlGST2 genes were constitutively expressed at all developmental stages, with increasing expression observed toward engorgement in the nymph and adult stages for HlGST and in all stages for HlGST2 genes

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Among these factors, enzyme mutations are the primary drivers of aberrant product formation, while the other conditions often act indirectly by altering enzyme conformation and promoting deviant catalytic routes