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This shift in understanding underscores the importance of targeting early-stage Tau aggregates rather than late-stage pathological inclusions to preserve cognitive function

We therefore propose a cell cyclecoupled alternation in which tetrasome/octasome states prevail immediately after CENP-A/H4 deposition in G1 and mature to the CENP-A nucleosome as H2A/H2B is incorporated in the S phase, with two illustrative CCAN-binding modes: RG-loop capture via CENP-N on subnucleosomal CENP-A/H4 assemblies and linker-DNA anchoring via CENP-C on the nucleosome (Figs 5 and S9), consistent with prior proposals of kinetochore plasticity (19, 39, 40, 41)

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