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Am J Physiol Renal Physiol 307(7):F777-82, 2014

K-means clustering was then performed using the scikit-learn Python library (random_state = 42, n_init = 10) to ensure reproducibility and robustness

In addition, by activating the PI3K/Akt pathway and speeding up the translocation of NFE2-Nrf2 to the nucleus via KEAP1 degradation, hASC-EV treatment significantly decreased oxidative damage

Intriguingly, several reports indicate that HIF1 binds and regulates the expression of multiple Jumonji-domain containing histone demethylases (JMJHDs), which may contribute directly to changes in hypoxic target gene expression 31,34

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