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Promote renal calcium reabsorption Renal tubular calcium transport: upregulate the expression of renal tubular calcium channel (TRPV5), reduce urinary calcium excretion by 30% -40%, increase blood calcium concentration, and increase bone calcium deposition Evidence from preclinical studies on AOD 9604 bone protection (animal experiments) Postmenopausal osteoporosis (OVX rat model) Experimental Design: Animal: 6-month-old female SD rats underwent bilateral ovariectomy (OVX) to establish a postmenopausal osteoporosis model

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The well-known geriatrician-haematologist Larry Solomon, working at Yale University in the USA, wrote 20 years ago: if I had treated only those people who actually had too low serum B12 and elevated MMA values, then I would not have treated approximately two-thirds of the people with a favourable response to B12 supplementation (note: partly via injections, partly via oral supplementation)