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doi: 10.1111/j.1471-4159.2006.03907.x 115

In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)

Notably, these alterations were not based on suppressed glycolysis, as BHB + T cells retained their glycolytic capacity (Fig EV1B and C)

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G6PD deficiency impairs redox control and increases susceptibility to oxidative damage and hemolysis (Luzzatto et al., 2020)