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Deficiency can lead to the faulty or insufficient production of lipids, from which myelin is composed (25, 26)

Some preclinical reports have indicated possible endothelial protective mechanisms, although these require additional validation in clinical research environments

Some causes of B12 deficiency are: Pernicious Anemia Autoimmune Diseases Leaky Gut Syndrome Ulcerative Colitis, Crohns and Celiac Disease Small Intestinal Bacterial Overgrowth (SIBO) H Pylori Infection Prolonged Usage of Gastric Reflux meds Vegan and Vegetarian diets MTHFR gene mutations Bariatric Surgeries Excessive Alcohol Consumption B12 and the Methylation Cycle: Methylation is a critical process that happens trillions of times in every cell each minute

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This study found that heat hyperalgesia was decreased with TRPV1 antagonism and that TRPV1 expression in large neurons in the trigeminal ganglia was increased