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Adv Exp Med Biol .2021;1286:77-85

Results showed that PBS-treated Tbx1 +/ mice had impaired PPI, as expected (Figs 6B and S6), whereas in vB12-treated Tbx1 +/ mice, the PPI response was indistinguishable from that of controls (Figs 6B and S7)

Moreover, the simulations confirmed that the Cagri P37 had weaker interactions with the ECDs leading to greater uncoupling of the peptide C-terminus from the ECDs (Supplementary Movie 1, Supplementary Tables 4, 5), and parallel increases in the dynamics of the peptide as it engaged with the CTR TM bundle, including F23