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Medial Prefrontal Cortex The Medial Prefrontal Cortex (mPFC) is involved with many cognitive functions and is comprised primarily of excitatory pyramidal neurons and a smaller population of inhibitory interneurons (Xu et al., 2019)

Figure 2 2.1 Changes in gut microbiota diversity associated with hypothyroidism The diversity and stability of the gut microbiota are sensitive indicators of health status, and disruptions to this microbial ecosystem are strongly associated with various chronic conditions, including hypothyroidism

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Pericytes also react to cytokines and triggers the release of proinflammatory molecules, which leads to BBB breakdown in vitro and induces activation of a proinflammatory state of astrocytes, endothelial cells, and microglia, the brains innate immune cell [31]

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