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Blood tests to ascertain levels of nutrients like vitamin B12 and calcium may also be done

At the molecular level, they modulate inflammation-related gene expression by altering membrane phospholipid composition, disrupting lipid raft integrity, inhibiting nuclear factor kappa B (NF-B), and activating PPAR- , thereby promoting anti-inflammatory mediators and suppressing inflammation (18)

10.1371/journal.pone.0164678 PLoS One 143 ShahD

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Autoimmune sclerosing cholangitis or overlap syndrome Diagnosis: Autoimmune sclerosing cholangitis or overlap (ASC/overlap) syndrome is characterized by the concurrent presence of features of both AIH and PSC, the evidence of the latter may be in the form of large duct PSC based on abnormal cholangiography on imaging (magnetic resonance or endoscopic retrograde) or small-duct PSC based on onion skinning periductal fibrosis on histology