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Embodiments of the invention also comprise one or more steps related to monitoring the effects or outcome of administration in order to evaluate the treatment protocol and/or to adjust the protocol as required or in a manner that is likely to provide more benefit, e.g

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This was coincidence with our findings where Propolis and Chlorhexidine groups showed a statistically significant low microleakage which in turn might reflect the good performance of such nanogels as they could perfectly disinfect the prepared cavities without retarding adhesion

Documented in animal-model literature for tissue remodeling, GI mucosal barrier signaling, and the cytoprotection paradigm