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Therefore, in the future, the one-size-fits-all intervention strategy should be abandoned in favor of precision intervention

They enable tumor cells to elude immune detection, and one of the ways they achieve this through modulating transcription of PD-L1 via miRNA sponging

3.2 Preclinical studies of ferroptosis in neurodegenerative diseases 3.2.1 Ferroptosis and alzheimers disease AD is a prevalent and progressive neurodegenerative disorder, characterized by the accumulation of extracellular -amyloid (A) plaques and intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein, accompanied by excessive neuroinflammation, synaptic dysfunction, and neuronal loss, ultimately resulting in impairments in language, judgment, and executive function, and even leading to the loss of independent living ability ( 1-42 stimulation markedly suppressed the activation of the bone morphogenetic protein 6 (BMP6)/SMAD1 signaling pathway in BV2 microglial cells, resulting in the downregulation of SLC7A11, GPX4, FTL1, and FTH1 expression, increased ROS and MDA levels, and decreased GSH and SOD levels

demonstrated that the levels and ratios of TG, TC, apo A1, and apo B were not associated with PSD (235, 236)

PLoS ONE 5:e9009