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Like glutathione, NAC has low bioavailability

However, the understanding of the ROS threshold in cancer cells is still unclear

Foods that boost glutathione or its precursors include: Sulfur-rich vegetables: broccoli, cauliflower, garlic, onions Protein sources: lentils, eggs, fish, poultry Avocados, spinach, okra Selenium-rich foods: Brazil nuts, sunflower seeds Supplements come in reduced glutathione or liposomal forms (the latter may have better absorption)

The TCA cycle is an essential hub for several metabolic pathways and for the interconversion of metabolites, which are renewed constantly in rapidly proliferating cancer cells 18

Furthermore, to characterize the effect of NAC on the invasion of GBM cells, we conducted Matrigel invasion assays