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however, it has 3 major limitations: a low success rate in reducing intrabody aggregation, insufficient correlation between the estimated net negative charge of intrabodies at pH 7.4 with experimentally determined stability, and a lack of in vivo validation for the targeting of endogenous proteins 4

Based on this, an approach based on CAR-T cells has been developed to eliminate senescent cells

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2000;2(4):665-671.[DOI] 77

Mechanisms for this diversity include epigenetic changes, specifically methylation, of the genes encoding these receptors, multiple isoforms of each receptor as a consequence of alternative RNA splicing and multiple sites of translation initiation of receptor mRNA (Hirata et al., 2003