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Given the lack of significant sex-based differences and the limited sample sizes within subgroups, all comparisons were performed using disease status as the primary variable to preserve statistical power and maintain analytical robustness

Oleocanthal inhibits catabolic and inflammatory mediators in LPS-activated human primary osteoarthritis (OA) chondrocytes through MAPKs/NF-B pathways

The Food and Drug Administration does not require a significant HbA1c reduction for drug approval, leading to less effective medications entering the market []

TIGAR protects against ischemic brain injury by enhancing PPP flux and maintaining mitochondrial function, so it may be a valuable therapeutic target for ischemic brain injury (Li et al., 2014)

Functions include direct ROS/RNS scavenging, control of cellular redox potential, and Phase II detoxification via GST-mediated conjugation (e.g., of NAPQI) to facilitate biliary/urinary excretion [114, 115]