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It seems that STAT3 signaling possesses the properties which might reprogram the phenotypes of both immune and non-immune cells to enhance the aging process and thus this phenomenon may be an important contributor to age-related diseases

IL-2 Gene Transfer for Chemosensitization of Multidrug-Resistant Human Colon Carcinoma Cells BT - Gene Therapy of Cancer.,

Diabetes 116 , 600605 (2008)

The only protection is realized via the strict control of iron metabolism ( Antioxidant defenses Antioxidants comprise the principal means of intracellular protection from free radical damage ( Non-enzymatic-defense The glutathione tripeptide molecule (GSH