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Genetic depletion of Slc7a11 or Gpx4 in mouse embryonic fibroblasts leads to ferroptosis [40, 41]

In vitro experiments revealed that high glucose-conditioned hippocampal neurons inhibited the differentiation of NSCs, and the application of an anti-RGMa antibody restored it

These included reductions in functional and cardiovascular age, greater exercise tolerance, and notably lower mortality: treated individuals had 28% fewer deaths overall, about half the cardiovascular mortality, and reduced incidence of heart failure & respiratory disease compared to controls

Treatment Resistance: High GSH levels confer significant resistance to anticancer drugs and radiation, as cancer cells use GSH to neutralize these therapies

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