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Therefore, several anticoagulant mechanisms regulate thrombin generation, including antithrombin, protein C inhibitor, heparin cofactor II, protease nexin 1, cartilage oligomeric matrix protein, and TFPI [3638]

Most current COF synthesis methods fall short of meeting Good Manufacturing Practice (GMP) standards in terms of yield, batch-to-batch consistency, cost efficiency, and the ability to produce sterile, pyrogen-free materials

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This interaction prevents the transcription of CHAC1, thereby reducing CHAC1 levels and subsequently decreasing the degradation of GSH