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In experimental autoimmune encephalomyelitis (a model of multiple sclerosis), berberine reduces the permeability of the blood-brain barrier and inhibits the activity of matrix metalloprotease 9 (MMP-9) in the cerebrospinal fluid and the brain of model mice (Ma et al., 2010)

It functions by sending electrical signals through these nerve cells

Rueckschloss U, Quinn MT, Holtz J, Morawietz H

Some research indicates that copper metabolism dysfunction in ALS may increase oxidative stress, foster lipid peroxidation and ferroptosis, and thus injure neurons (122)

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