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In the chromaffin cells of the adrenal medulla, a methyl group is provided by SAMe, resulting in the formation of epinephrine from norepinephrine

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J Nucl Med 60(2):279-284, 2018

The first is via glutamate dehydrogenase (GLDH), which produces the potential autophagy inducer ammonium and NADH or NADPH as cofactors