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Moreover, the rhPDGF-BB group can mitigate several issues associated with autogenous bone grafts, such as blood loss, scarring, extra surgical time, and donor pain [415]

The insertion should be swift and decisive hesitant, slow insertions increase pain

Sublingual B12 was administered in laboratory conditions, where there was no dose omission, making it difficult to extrapolate real-world effects, where patient compliance may not be as good