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Lifelong voluntary aerobic exercise protocols have been shown to largely prevent age- and western diet-induced vascular endothelial dysfunction and arterial stiffening throughout the lifespan in mice, and this protective effect appears to be mediated by the mitigation of mitochondrial-derived oxidative stress and inflammation [116]

Role of histone methylation and demethylation in adipogenesis and obesity

This paper describes how mitochondria produce ROS

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N-acetylcysteine attenuates myocardial dysfunction and postischemic injury by restoring caveolin-3/eNOS signaling in diabetic rats