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Even when intraperitoneal drug levels are increased, therapeutic benefit remains constrained by tumor adaptation and tolerance programs shaped by the peritoneal microenvironment

10.1016/j.cell.2011.10.026 17

Particularly the methionine and cysteine residues in Tesamorelin's sequence

It acts as a potent agonist of the Ghrelin Receptor (GHS-R1a), mimicking the hunger hormone ghrelin to stimulate the release of Growth Hormone (GH) from the pituitary gland