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In the latter case, the cofactor can also be considered a substrate or cosubstrate

doi: 10.1007/s00401-022-02412-9 37 BrownR

To determine absolute configuration, phenolic position of both enantiomers was esterified with 1.2 molar equivalents of 4-nitrobenzoyl chloride and 2 molar equivalents of triethylamine in anhydrous THF