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This is speculative, but it's not dismissable

If the intestinal lining is damaged by inflammation, infection, or bacterial overgrowth, those receptors do not function properly

The role of adenosine receptors A2A and A2B signaling in renal fibrosis

Fullagar B, Rao W, Gilor C, Xu F, He X, Adin CA

Of course, OxyR does not induce glutaredoxin 1 and thioredoxin 2 for no reasonso we were surprised by our inability to observe any phenotype for grxA and trxC deletions during H 2 O 2 stress