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Further studies are also focused on the potential therapeutic benefits of lowering homocysteine levels in various diseases

The samples were subsequently incubated with 10 M mitoSOX working solution at 37 C for 30 min under light-protected conditions, followed by nuclear staining with Hoechst 33,342 solution for 5 min

While many of those results may be attributed to GSH depletion, the contribution of GCLC to -glutamyl peptide synthesis and glutamate scavenging may also play a very important role, particularly in the context of xCT inhibition, where cells cannot export glutamate

The exclusion criteria were patients: (1) on diuretics in the emergency setting

Askarizadeh M, Esfandiari N, Honarvar B, Sajadian SA, Azdarpour A