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This effect of RRM1 silencing on erastin2-induced ferroptosis was specific: RRM1 silencing did not inhibit cell death in response to several mechanistically distinct small molecule inducers of apoptosis or other forms of non-apoptotic cell death that are not directly linked to intracellular GSH metabolism (Ko et al, 2019) (Fig S4A)

371 Src kinases also participate in GPCR-mediated signaling to regulate neutrophil functions through activating downstream pathways, such as PI3K, MAPK, and NF-B

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This removes the water without passing through a liquid phase, which is incredibly gentle on the complex, folded structure of the peptide