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High levels of inflammation are present in virtually every chronic illness, like diabetes, heart disease, and cancer

As a result, almost every PRR has been implicated in progression of ALD (6, 60) (Figure 2), including intracellular receptors such as TLR3/7/8/9, cGAS, AIM2, NLRs, and extracellular receptors such as TLR2/4 and the C-type lectin receptors (CLRs)

Regarding the inflammatory component in neuronal disorders, ALA and DHLA inhibit inflammasomes in neural tissues by decreasing pro-inflammatory mediators, such as interleukin-2 (IL-2), IFN-, and TNF-, increasing anti-inflammatory cytokines such as interleukin-10 (IL-10), and regulating the transcription of nuclear factors Nrf2 and NF-B in physiological processes

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In addition to AGE and SAC, fresh garlic and its most bioactive component Allicin are also reported to elicit NO-dependent vasodilation