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doi: 10.1016/j.parint.2021.102488 85 MaizelsRMBalicAGomez-EscobarNNairMTaylorMDAllenJE

Analysis of breast tumor tissues confirmed the increased level of DNA damage, most likely attributed to the formation of 4-hydroxy estradiol (4-OHE) mediated by cytochrome P450, which in turn can trigger the formation of ROS such as H 2 O 2 that are catalytically decomposed to OH radicals via the iron-Fenton reaction

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However, research shows that neurological and psychiatric symptoms can occur even with levels under 500 pg/mL (OLeary & Samman, 2010)

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