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Vitiello MV, Moe KE, Merriam GR, et al

ASN Neuro 12 , 1759091420962681

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Both preclinical (in vitro and in vivo) and clinical studies were considered for inclusion to provide a broad perspective on the current state of evidence

NAD metabolism and mitochondria also provides a link to inflammaging, as low NAD+ levels or oxidized mitochondrial DNA induce activation of NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome, a sensor of the damageassociated molecular patterns (DAMPs) that accumulate with aging