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Jiang, D

Carman AJ, Mills JH, Krenz A, Kim DG, Bynoe MS

Punicalagin (CAS 65995-63-3) and punicalin (CAS 65995-64-4) were obtained from BOC Science (Shirley, NY, USA) and Apollo Scientific (Stockport, UK), respectively

When activated, the mast cells in the skin release mediators (histamines, tryptase, TNF-alpha, CXCL9, etc.) that cause inflammation, flushing, itching, or burning.[ref] Related article: Rosacea, underlying causes, genetic susceptibility Dermatographism and mast cell activation syndrome: In a survey of mast cell activation syndrome, dermatographism was found in 89% of the patients.[ref] Dermatographism is when you get welts or raised red lines when you scratch your skin lightly