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For maximum effectiveness, extend this to 2-3 hours post-administration before consuming significant calories

Kwasniak-Owczarek M, Kazmierczak U, Tomal A, Mackiewicz P, Janska H

Daily subcutaneous administration is the standard research protocol

For an older person on vitamin B12 injections, once the blood level of vitamin B12 has normalized, the injections can be given once a month