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RS is an autosomal dominant disorder in which all affected individuals reported to date are heterozygous at the H1-4 locus and therefore express both mutant and WT H1.4

Hanwell, M

The translation of these findings to human disease is unclear, but suggest existing vascular injury, reduced BBB integrity, and/or neuroinflammation in the context of diabetes and advanced age, may increase an individuals risk for CNS infection

This underscores its potential as a supportive treatment and addresses the interplay between metabolic and inflammatory aspects of the disease

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