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These findings suggest that FSP1 is a vitamin K reductase that maintains a warfarin-resistant non-canonical vitamin K cycle and inhibits ferroptosis by producing VK-H 2 via NADH consumption to prevent lipid peroxidation

Deficiencies can occur at several different locations in the pathway and result in albinism (tyrosinase), alkaptonuria (homogentisate oxidase), or tyrosinemia, which can manifest due to deficiencies in several enzymes along the pathway (figure 8.2)

Lewis et al., 1997

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