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Moderate ER stress induction is correlated to the activation of the pro-survival genes that regulates amino acid metabolism, ER chaperones, redox reaction, protein folding, and autophagy [361]

2025 Jan 13:e2413728

The predominant molecular characteristics of ED are compromised production and function of NO, as well as heightened oxidative stress [37]

Cytosolic thiol switches regulating basic cellular functions: GAPDH as an information hub

Though the majority of metabolites do not differentially accumulate in tumor tissue compared to normal lung, we determined that a subset of metabolites is enriched in NSCLC tumors including reduced glutathione (GSH) (Supplementary Fig